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Week
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Topics
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Study Metarials
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1
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The importance of biochemical approach to drug design
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R3: Chapter 1
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2
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Metabolic targets on drug action
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R1: Chapter 1
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3
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Drug-target intermolecular interactions
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R3: Chapter 2
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4
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Proteins as Drug Targets
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R2: Chapter 3
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5
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Enzymes as Drug Targets
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R2: Chapter 4
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6
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Receptors as Drug Targets
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R2: Chapter 5
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7
|
Nucleic acids as Drug Targets
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R2: Chapter 6
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8
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Nucleic acids as Drug TargetsNucleic acids as Drug Targets
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R2: Chapter 7
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9
|
Predicting ADME Properties of Chemicals
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R2: Chapter 11
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10
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Protein?Ligand Docking
|
R3: Chapter 11
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|
11
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Docking Programs
|
R3: Chapter 11
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12
|
Molecular Docking Simulations
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R3: Chapter 11
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|
13
|
Chemoinformatics
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R1: Chapter 5
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14
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Chemoinformatics databases
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R1: Chapter 5
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Prerequisites
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-
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Language of Instruction
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Turkish
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Responsible
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Assoc. Prof. Dr. Şevki ADEM
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Instructors
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-
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Assistants
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-
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Resources
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R1: Leszczynski J. (2017), Handbook of Computational Chemistry, Second Edition Springer International Publishing, Switzerland.
R2. Patrick GL.( 2008) An Introduction to Medicinal Chemistry, Oxford UniversityPress, 752, NewYork
R3.Nogrady T. Weaver DF. (2005). Medicinal Chemistry: A Molecular and Biochemical Approach. Oxford University Press, 665, NewYork
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Supplementary Book
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-
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Goals
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The aim of this course is to show students the mechanisms of action of drugs and to teach the approaches applied in the design of drug active substances.
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Content
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The importance of biochemical approach to drug design, Metabolic targets on drug action, Drug-target intermolecular interactions, Proteins as Drug Targets, Enzymes as Drug Targets, Receptors as Drug Targets, Nucleic acids as Drug Targets, The methods used in drug development, Predicting ADME Properties of Chemicals, Protein?Ligand Docking, Docking Programs, Molecular Docking Simulations, Chemoinformatics, Chemoinformatics databases
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Program Learning Outcomes |
Level of Contribution |
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1
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Has the necessary theoretical and applied basic knowledge within the scope of natural science. Has the knowledge to evaluate the nature, source, limits, accuracy, reliability, and validity of the information.
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3
|
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2
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Participates in interdisciplinary studies by using the basic knowledge of the field and analytical thinking ability.
|
-
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3
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Evaluates concepts, ideas, and data in the field of chemistry with scientific methods, identify and analyze complex problems and issues, make discussions, and develop suggestions based on evidence and research.
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3
|
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4
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Has the ability to design and implement experiments, use modern technical devices, collect data and analyze results in order to research and solve problems related to the field.
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3
|
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5
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Produces solutions by taking responsibility for solving unpredictable complex situations in applications in the field of chemistry.
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-
|
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6
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Informs periodically the people and institutions it is responsible for while conducting studies related to its field, and expresses its findings and suggestions for solutions to emerging problems in written, oral, and, if necessary, visual presentation.
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-
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7
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Determines the theoretical and practical deficiencies related to the field and directs the future learning processes.
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-
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8
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Has the knowledge of a foreign language at a level to be able to access the scientific information needs from foreign sources related to the field, update knowledge, and communicate with colleagues around the world.
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-
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9
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Uses computer software, information, and communication technologies at the level required by the field and accesses scientific resources in this way.
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-
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10
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Develops strategy, policy, and implementation plans on issues related to the field and manages the data obtained within the framework of quality processes.
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3
|
|
11
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Supervises and checks the social, scientific, cultural, and ethical values at the stages of collection, interpretation, application, and announcement of the data related to the field.
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-
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