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Week
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Topics
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Study Metarials
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1
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The description and importance of asymmetric synthesis.
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R1: CHAPTER 1
R2: CHAPTER 1, 2
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2
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The description of stereochemistry (Chirality, configuration, conformation, enantiomers, diastereomers, meso, optically active and inactive compounds, enatioselective and diastereoselective reactions)
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R1: CHAPTER 1, 2
R3: CHAPTER 1, 4, 5
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3
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Asymmetric Induction (Chiral pool), asymmetric synthesis (chiral auxiliaries)
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R1: CHAPTER 4, 5
R3: CHAPTER 14, 15
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4
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Asymmetric Synthesis: Chiral reagents, chiral catalysts and ligands
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R1: CHAPTER 6
R3: CHAPTER 15
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5
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Asymmetric aldol reactions
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R1: CHAPTER 6
R2: CHAPTER 5
R3: CHAPTER 8
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6
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Asymmetric Oxidation: Asymmetric epoxidation, asymmetric oxidation of sulfides
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R1: CHAPTER 6
R2: CHAPTER 7
R3: CHAPTER 10
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7
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Asymmetric Oxidation: asymmetric dihydroxylation, chiral oxaziridines and their uses.
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R1: CHAPTER 6
R3: CHAPTER 10
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8
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Asymmetric Reduction: Catalytic hydrogenation, asymmetric hydroboration of alkenes, chirally modified LiAlH4, enzymatic reduction
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R1: CHAPTER 6
R2: CHAPTER 7
R3: CHAPTER 15
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9
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Asymmetric addition to carbonyl compounds, alpha-substitution using chiral enolate.
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R1: CHAPTER 5
R2: CHAPTER 3, 4
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10
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Asymmetric Diels-Alder Reactions
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R1: CHAPTER 6
R2: CHAPTER 6
R3: CHAPTER 15
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11
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Asymmetric Alkylation
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R1: CHAPTER 6
R3: CHAPTER 15
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12
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Asymmetric Michael reaction and rearrangements
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R1: CHAPTER 5, 6
R3: CHAPTER 8
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13
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Analytical methods: determination of enantiomeric purity : Polarimetric, gas chromatography methods and NMR spectroscopy
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R1: CHAPTER 3
R3: CHAPTER 6
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14
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Asymmetric total synthesis. The synthesis of (+)-thienamycin, ( R )-muscone, (+ )-alpha-Allokainic acid and (S )- (-)-Propranolol and so on
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R1: CHAPTER 7
R3: CHAPTER 16
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Prerequisites
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-
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Language of Instruction
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Turkish
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Responsible
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Prof. Dr. Zeynep GÜLTEKİN
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Instructors
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-
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Assistants
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---
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Resources
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R1. Aitken, R.A.; Kilényi, S.N., (1992), Asymmetric Synthesis, Blackie Academic &Professional.
ISBN 0 7514 0190 0
R2. Procter, G., (1996), Asymmetric Synthesis, Oxford University Press, New York.
ISBN 019855726
R3. Buxton,S. R, Roberts S.M. (1996), Guide to Organic Stereochemistry from methane to macromolecules.
Addision Wesley Longman Limited. ISBN 0-582-23932-X.
Related Websites: www.elsevier.com, www.Sciencedirect.com, www.rsc.org, www.sciencefinder.com
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Supplementary Book
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-
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Goals
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To give students experience of the importance of asymmetric synthesis and how to synthesize enantiomerically pure organic compounds by this way.
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Content
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The description of stereochemistry. Asymmetric synthesis methods. Aldol, Diels-Alder, alkylation, rearrangements, Michael, oxidation and reduction reactions using asymmetric synthesis method. Determination of enantiomeric purity by analyticals method. Asymmetric total synthesis of natural or non-natural molecules.
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Program Learning Outcomes |
Level of Contribution |
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1
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Based on the competencies of the doctorate, to develop and deepen the current and advanced knowledge in the field with original thinking and research at the level of expertise and to reach original definitions that will bring innovation to science.
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4
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2
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Understanding the interaction between the disciplines related to the field of chemistry; to achieve original results by using expertise in analyzing, synthesizing and evaluating new and complex ideas.
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-
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3
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To reach new scientific knowledge in the field of chemistry and to gain high level skills in research methods related to the field.
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4
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4
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To be able to develop a new scientific method in the field of chemistry or to apply a known method to a different problem.
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4
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5
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To be able to research, comprehend, design, adapt and apply an original subject.
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-
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6
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To be able to question, synthesize and evaluate new and complex ideas.
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3
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7
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Publishing original studies in peer-reviewed journals.
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-
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8
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To be able to develop original ideas and methods related to the field and interdisciplinary by using high level mental processes such as creative and questioning thinking, problem solving and decision making
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-
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9
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To be able to present their original views effectively in a professional community.
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-
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10
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To be able to communicate and discuss in at least one foreign language at an advanced level, written, oral and visual.
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-
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11
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To contribute to the process of becoming an information society by introducing technological advances in academic and professional contexts.
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4
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