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Week
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Topics
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Study Metarials
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1
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Importance of synthetic chemistry, multistep chemical synthesis, retrosynthetic analysis , transform and retrons
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R1: CHAPTER 1
R2: CHAPTER 1, 2
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2
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Sythesis of Strychnine and Penicillin V (retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 2, 3
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3
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Sythesis of Reserpine and Progesterone (retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 4, 6
R2: CHAPTER 13
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4
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Sythesis of Carpanone and Vitamin B12
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 7, 8
R2: CHAPTER 3, 13
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5
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Sythesis of Prostaglandin A2 and Prostaglandin F2a
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 9
R2: CHAPTER 11
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6
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Sythesis of Estrone, Eryhronolide B and monensin
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 10, 11, 12
R2: CHAPTER 2, 7, 13
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7
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Sythesis of Isocomene and Endiandric Acids
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 14 , 17
R2: CHAPTER 13
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8
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Sythesis of Biotin, L-Hexoses and Asteltoxin
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 18, 19, 20
R2: CHAPTER 8, 13
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9
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Sythesis of Periplanone B, Menthol, Amphoteronolide B and Amphotericin B
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 22, 24
R2: CHAPTER 13
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10
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Sythesis of Ginkgolide B and Thienamycin (retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 16, 25
R2: CHAPTER 3, 6, 13
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11
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Sythesis of Indolizomycin and Cytovaricin
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 27, 28
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12
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Sythesis of Taxol, Zaragozic acid A and Brevetoxin B
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 34, 35, 37
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13
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Sythesis of Palytoxin and Rapamycin
(retrosynthetic analysis and strategy, total synthesis)
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R1: CHAPTER 31, 33, 36
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14
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Sythesis of Macrocyclic structure
(retrosynthetic analysis and strategy, total synthesis)
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R2: CHAPTER 7
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Prerequisites
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-
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Language of Instruction
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Turkish
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Responsible
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Prof. Dr. Zeynep GÜLTEKİN
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Instructors
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-
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Assistants
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---
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Resources
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R1. Nicolaou, K.C.; Sorensen, E.J. (1996), Classics In Total Synthesis.
ISBN: 3-527-2984-5
R2. Corey, E.J.; Cheng, X-M. (1989), The Logic of Chemical Synthesis, John Wiley
& sons. ISBN: 0-471-50979-5
Related Websites: www.elsevier.com, www.Sciencedirect.com, www.rsc.org, www.sciencefinder.com
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Supplementary Book
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-
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Goals
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The aim of this course is to gain experience in the total synthesis of targeted organic molecules, as well as to gain experience in the retrosynthetic analysis strategy and reaction mechanisms of these molecules.
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Content
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Importance of synthetic organic chemistry. Retrosynthetic analysis. Total synthesis of Strychnine, Penicillin V, Reserpine, Progesterone, Carpanone, Vitamin B12, Prostaglandin A2, Prostaglandin F2a, Estrone, Eryhronolide B, monensin, Isocomene, Endiandric Acids, Biotin, L-Hexoses, Asteltoxin, Periplanone B, Menthol, Amphoteronolide B, Amphotericin B, Ginkgolide B, Thienamycin, Indolizomycin and Cytovaricin, Taxol, Zaragozic acid A and Brevetoxin B, Palytoxin, Rapamycin and macrocyclic compounds.
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Program Learning Outcomes |
Level of Contribution |
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1
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Based on the competencies of the doctorate, to develop and deepen the current and advanced knowledge in the field with original thinking and research at the level of expertise and to reach original definitions that will bring innovation to science.
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4
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2
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Understanding the interaction between the disciplines related to the field of chemistry; to achieve original results by using expertise in analyzing, synthesizing and evaluating new and complex ideas.
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3
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3
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To reach new scientific knowledge in the field of chemistry and to gain high level skills in research methods related to the field.
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4
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4
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To be able to develop a new scientific method in the field of chemistry or to apply a known method to a different problem.
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4
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5
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To be able to research, comprehend, design, adapt and apply an original subject.
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3
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6
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To be able to question, synthesize and evaluate new and complex ideas.
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-
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7
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Publishing original studies in peer-reviewed journals.
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-
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8
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To be able to develop original ideas and methods related to the field and interdisciplinary by using high level mental processes such as creative and questioning thinking, problem solving and decision making
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-
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9
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To be able to present their original views effectively in a professional community.
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-
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10
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To be able to communicate and discuss in at least one foreign language at an advanced level, written, oral and visual.
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-
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11
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To contribute to the process of becoming an information society by introducing technological advances in academic and professional contexts.
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-
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